DILCTM
DIrect inject
liquid chromatography
transforms conventional “offline” HPLC analysis into a powerful new “online” tool
What is DILCTM
Direct Inject Liquid Chromatography (DILCTM) is a hardware and software ecosystem that enables direct sampling and analysis of chemical reactions. The system consistently samples your reaction vessel and delivers aliquots to an external liquid chromatography instrument for real-time analysis.
DILCTM enables unattended sample capture, quenching, dilution, and analysis using a variety of industry standard CDS platforms including Agilent Openlabs, Agilent Chemstation, Waters Empower 3, and Shimadzu Labsolutions.
DILCTM is the only tool that works together with Mettler Toledo iC LC software for sample scheduling and data acquisition.
Real-time data
direct decision-making
reaction optimization
Reaction profiling
Beyond end-point analysis
DILCTM brings the ability to monitor the full reaction progress in real time, providing the complete concentration and composition profile for nearly any chemical process.
Explore mechanistic pathways, the impacts of side-products and intermediates, catalytic activity, reaction kinetics, and reaction optimization.
Academic publications
Deem, M. C. et al. “Ring walking as a regioselectivity control element in Pd-catalyzed C-N cross-coupling.” Nature Commun. 2022.
Christensen, M. et al. “Development of an automated kinetic profiling system with online HPLC for reaction optimization.” React. Chem. Eng. 2019.
Malig, T. C. et al. “A revised mechanism for the Kinugasa reaction.” J. Am. Chem. Soc. 2018.
Malig, T. C. et al. “Real-Time HPLC-MS reaction progress monitoring using an automated analytical platform.” React. Chem. Eng. 2017.
Complex chemical systems
Previously intractable conditions
This innovative system was designed to meet the demands of the most challenging chemical processes, including solid-liquid slurries, biphasic systems, air/water sensitive reactions, cryogenic transformations, and gas/liquid processes under high pressure.
Academic publications
Deem, M. C. et al. “Ring walking as a regioselectivity control element in Pd-catalyzed C-N cross-coupling.” Nature Commun. 2022.
Sato, Y. et al. “Real-Time monitoring of solid-liquid slurries: Optimized synthesis of tetrabenazine.” J. Org. Chem. 2021.
Malig, T. C. et al. “Online HPLC analysis of Buchwald-Hartwig aminations from within an inert environment.” ACS Cat. 2020.
crystallization
Track and optimize crucial process chemistry
DILCTM is compatible with selective solution phase sampling from dynamically crystallizing reactions in real time. Rapidly design and qualify chiral resolutions, selective crystallizations, and crystallization induced asymmetric transformations.
Academic publications
Kukor, A. J. et al. “Enantioselective synthesis of (-)-tetrabenazine via continuous crystallization-induced diastereomer transformation.” Chem. Sci. 2022.
Kukor, A. J. et al. “A robust new tool for online solution-phase sampling of crystallizations.” React. Chem. Eng. 2021.
Rougeot, C. et al. “Automated reaction progress monitoring of heterogeneous reactions: crystallization-induced stereoselectivity in amine-catalyzed aldol reactions.” React. Chem. Eng. 2017.
